Preparation and handling of chemotherapy agents

  • Preparation and handling of chemotherapy agents
    • May pose an occupational hazard
    • Drugs may be absorbed through
      • Skin
      • Inhalation during preparation, transportation, and administration
    • Only properly trained personnel should handle cancer drugs
  • Chemotherapy methods of administration
    • Oral
      • More available options today
      • Storage and side effects
    • IM – Intramuscular
    • IV – Intravenous (most common)
      • Central venous access device (CVAD)
    • CVAD administration
      • Placement in large blood vessels
      • Frequent, continuous, or intermittent administration
      • Can be used to administer other fluids (blood, electrolytes, etc.)
  • Regional administration
    • Delivery of drug directly into
      tumor site
    • Higher concentrations of drug can be delivered with less systemic toxicity
    • Types of regional delivery methods
      • Intraarterial
        • Delivers drug through arteries supplying tumor
      • Intraperitoneal
        • Delivers drug to peritoneal cavity for treatment of peritoneal metastases
      • Intrathecal or intraventricular
        • Involves lumbar puncture and injection of chemotherapy into subarachnoid space
      • Intravesical bladder
        • Agent added to bladder by urinary catheter and retained for 1 to 3 hours
  • Effects on normal tissue
    • General and drug-specific adverse effects are classified
      • Acute
      • Delayed
      • Chronic
  • Radiation therapy
    • One of the oldest nonsurgical methods of cancer treatment
    • 50% of all cancer patients will receive radiation therapy at some point in their treatment
    • Radiation is emission of energy from a source and travels through space or some material
    • Different types of ionizing radiation are used to treat cancer
    • Technologic advances
      • Low-energy beams
        • Expend energy quickly
        • Penetrate a short distance
        • Useful for skin lesions
      • High-energy beams
        • Greater depth of penetration
        • Suitable for optimal dosing of internal targets while sparing skin
    • Total doses divided into fractions
    • Typically delivered once a day for 5 days a week for 2 to 8 weeks
      • Standard fractionation

Share:

More Posts

Facts About Falls

AT A GLANCE Each year, millions of older people—those 65 and older—fall. In fact, more than one out of four older people falls each year,

About Healthy Weight and Growth

KEY POINTS Parents and caregivers can help children have healthy growth and a healthy weight. Achieving healthy growth and weight includes healthy eating, physical activity,

Preventing Mosquito Bites

KEY POINTS Take steps to protect yourself and your family from mosquito bites that can make you sick. Use Environmental Protection Agency (EPA)-registered insect repellents.