Inflammation : Chemical mediators

Chemical mediators

  • Histamine
    • Stored in granules of basophils, mast cells, platelets
      • Causes vasodilation and increased capillary permeability
  • Serotonin
    • Stored in platelets, mast cells, enterochromaffin cells of GI tract
      • Causes vasodilation and increased capillary permeability like histamine.
      • Stimulates smooth muscle contraction
  • Kinins (e.g., bradykinin)
    • Produced from precursor factor kininogen as a result of activation of Hageman factor (XII) of clotting system
      • Cause contraction of smooth muscle and vasodilation.
      • Result in stimulation of pain
  • Complement system (C3a, C4a, C5a)
    • Anaphylatoxic agents generated from complement pathway activation
      • Stimulate histamine release and chemotaxis
      • Final components of complement system create holes in cell membrane, causing targeted cell death by membrane rupture
  • Prostaglandins and leukotrienes
    • Produced from arachidonic acid
      • PGs cause vasodilation. LTs stimulate chemotaxis
  • Cytokines


More Posts

Breast Cancer Awareness Month

October is Breast Cancer Awareness Month, an annual campaign to raise awareness about the impact of breast cancer. BCAM-2022-Community-Sharing-Calendar Original Article –

Shoulder Injuries and Disorders

Summary Your shoulder joint is composed of three bones: the clavicle (collarbone), the scapula (shoulder blade), and the humerus (upper arm bone). Your shoulders are

Stroke Signs and Symptoms

Learn what to do if you or someone else is having a stroke. During a stroke, every minute counts! Fast treatment can lessen the brain damage