Role of immune system

Immune response is to reject or destroy cancer cells
- May be inadequate as cancer cells arise from normal human cells
Some cancer cells have changes on their surface antigens
- Tumor-associated antigens (TAAs)
Cytotoxic T cells
- Kill tumor cells directly
- Produce cytokines
Natural killer cells and activated macrophages can lyse tumor cells
B cells produce antibodies that bind to tumor cells

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