| Genitourinary Tract | ||
| Hemorrhagic Cystitis | Cells lining bladder are destroyed by chemotherapy (e.g., cyclophosphamide, ifosfamide).
Side effect of radiation when located in treatment field. |
Encourage increased fluid intake 24-72 hr after treatment as tolerated.
Monitor manifestations such as urgency, frequency, and hematuria. Administer cytoprotectant agent (mesna [Mesnex]) and hydration. Administer supportive care agents to manage symptoms (e.g., lavoxate [Urispas]). |
| Reproductive Dysfunction | Cells of testes or ova are damaged by therapy. | Discuss possibility with patients before treatment initiation.
Offer opportunity for sperm and ova banking before treatment for patients of childbearing age. |
| Nephrotoxicity | Direct renal cell damage from exposure to nephrotoxic agents (cisplatin and high-dose methotrexate).
Precipitation of metabolites of cell breakdown (tumor lysis syndrome [TLS]). |
Monitor BUN and serum creatinine levels.
Avoid potentiating drugs. Alkalinize the urine by adding sodium bicarbonate to IV infusion and administer allopurinol (Zyloprim) or rasburicase for TLS prevention |
Keeping kids safe on trampolines and at bounce houses
October 27, 2021• By Angela Mattke, M.D., Mayo Clinic Press Editors Trampolines and bounce houses have become staples of backyards, community and family events, and
